Natural regulatory T cells and persistent viral infection.
نویسندگان
چکیده
Natural Regulatory T Cells and Persistent Viral Infection Shuo Li,* Eric J. Gowans, Claire Chougnet, Magdalena Plebanski, and Ulf Dittmer HCV Laboratory, Macfarlane Burnet Institute, GPO Box 2284, Melbourne, VIC 3001, Australia; Department of Microbiology, Monash University, Melbourne, Australia; Division of Molecular Immunology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229-3039; Department of Immunology, Monash University, Melbourne, Australia; and Institute for Virology, University Clinics Essen, University Duisburg-Essen, 45122 Essen, Germany
منابع مشابه
Expansion of CD4+CD25+FoxP3+ Regulatory T Cells in Chronic Hepatitis C Virus Infection
Background: Regulatory T cells (Tregs) have been involved in impaired immunity and may have a pivotal role in persistence of viral infections. Objective: To develop a simple and reliable in-house three color flow cytometery of peripheral blood to understand the role of HCV infection in the increase of Tregs. Methods: The level of naturally occurring CD4+CD25+FoxP3+ regulatory T cells (nTregs) i...
متن کاملFoxp3+ Regulatory T Cells Control Persistence of Viral CNS Infection
We earlier established a model of a persistent viral CNS infection using two week old immunologically normal (genetically unmodified) mice and recombinant measles virus (MV). Using this model infection we investigated the role of regulatory T cells (Tregs) as regulators of the immune response in the brain, and assessed whether the persistent CNS infection can be modulated by manipulation of Tre...
متن کاملPrevalence of Persistent Bovine Viral Diarrhea Infection in Industrial Dairies of Tehran and Alborz Province, Iran
Background and Aims: Bovine viral diarrhea virus (BVDV) is considered as worldwide and economically significant infection. The aim of this study was to estimate prevalence of persistent bovine viral diarrhea infection (PI) in industrial dairies of Tehran and Alborz province, Iran. Materials and Methods: In this cross-sectional study, 102371 blood samples were collected from bovine of industria...
متن کاملViral infection prevents diabetes by inducing regulatory T cells through NKT cell–plasmacytoid dendritic cell interplay
Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell-mediated destruction of insulin-producing β cells, and viral infections can prevent the onset of disease. Invariant natural killer T cells (iNKT cells) exert a regulatory role in T1D by inhibiting autoimmune T cell responses. As iNKT cell-plasmacytoid dendritic cell (pDC) cooperation controls viral replication in the pancreati...
متن کاملA novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells.
Restrictions in the diversity of an adaptive immune repertoire can facilitate viral persistence. Because a host afflicted with an immune deficiency is not likely to purge a persistent infection using endogenous mechanisms, it is important to explore adoptive therapies to supplement the host with a functional immune defense. In this study, we describe a virus carrier state that results from intr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of virology
دوره 82 1 شماره
صفحات -
تاریخ انتشار 2008